Maturation programs
نویسندگان
چکیده
منابع مشابه
Transcriptional Programs Controlling Perinatal Lung Maturation
The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In ...
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Cardiac progenitors are specified early in development and progressively differentiate and mature into fully functional cardiomyocytes. This process is controlled by an extensively studied transcriptional program. However, the regulatory events coordinating the progression of such program from development to maturation are largely unknown. Here, we show that the genome organizer CTCF is essenti...
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Being deeply connected to signalling, cell dynamics, growth, regulation, and defence, endocytic processes are linked to almost all aspects of cell life and disease. In this review, we focus on endosomes in the classical endocytic pathway, and on the programme of changes that lead to the formation and maturation of late endosomes/multivesicular bodies. The maturation programme entails a dramatic...
متن کاملImmunological Maturation
Immunological maturation, the gradual increase in affinity for antigen of serum antibody with time after immunization, has been postulated to result from a competition among precursors of antibody-forming cells for available antigen (1, 2). Thus, as the antigen concentration in the cellular environment falls, only those cells with antigen-binding receptors of sufficiently high avidity to captur...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2020
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-020-0655-z